Der Pharmacia Lettre
Abstract
Author(s): Arun Singh, Deepak Kumar and F.B.Bux
2-(5-benzoyl-1H-benzo[d]imidazol-1-yl) acetohydrazide (3) undergoes facile condensation with
aromatic aldehydes to afford the corresponding 2-(5-benzoyl-1H-benzo[d]imidazol-1-yl)-N'-
alkylidene aceto hydrazide (4a-h) in good yields. Cyclocondensation of compounds (4a-h) with
thioglycolic acid yields 3-(2-(5-benzoyl-1H-benzo[d]imidazol-1-yl) acetyl)-2-alkylthiazolidin-4-
one (5a-h). These (5a-h) compounds are for the reacted with benzaldehyde in the presence of
sodium ethanolate affords, giving 3-(2-(5-benzoyl-1H-benzo[d]imidazol-1-yl) acetyl)-5-
benzylidene-2-alkylthiazolidin-4-one (6a-h). The structures of these compounds were established
on the basis of analytical and spectral data. All the newly synthesized compounds were evaluated
for their antibacterial and antifungal activities.
