Synthesis of phosphorylated urea/ thio-urea derivatives was accomplished by the reaction of isocayanates/isothiocayanates with diethyl phosphoramidate at 10 to 40 0C. All the compounds were characterized by IR, NMR (1H, 13C, 31P), Mass spectral analysis. These compounds were screened for Anti-microbial activity and exhibited promising results.
