Flavonoids are one of the active principles isolated from plant sources. These compounds have found to have enormous pharmacological activity, Hesperidin, a molecule with a wide spectrum of pharmacological activity still has not been used for treatment of any diseases due to its lacking potency. The present study was focused to synthesize various derivatives of Hesperidin and to evaluate their activity. Among the various synthesized compounds, compound Hg, Hn and Hj have shown more potent activity even when compared with the compound. Whereas all other compounds were not potent as standard compound but were found to have increased in potency while comparing with the standard compound. Thus we conclude substitution of the oxygen moiety with the hydrazide to form hydrazones increases the antibacterial activity and presence of electron donating groups further increases the activity.
