Der Pharmacia Lettre
Abstract
Author(s): Govindaraj Saravanan, Perumal Pannerselvam and Chinnasamy Rajaram Prakash
In the present study, a novel Schiff bases were synthesized by condensation of 3-amino-2-methyl
quinazolin-4-(3H)-ones with different aromatic aldehydes. The 3-amino-2-methyl quinazolin-4-
(3H)-one was synthesized from anthranilic acid via 2-methyl Benzoxazin-4-one. The chemical
structures of the synthesized compounds were confirmed by means of IR, 1H-NMR, 13C-NMR,
Mass spectral and Elemental analysis. These compounds were screened for the analgesic activity
by tail-immersion method and also for anti-inflammatory activity by carrageenan induced paw
oedema method in rats at a dose of 100 mg/kg body weight. Among the tested compound 3-(4-
methylbenzylideneamino)-2-methyl quinazolin-4-(3H)-one (4f) exhibited better analgesic
activity when compared to standard pentazocine. Out of twelve synthesized compounds 3-(4-
hydroxybenzylideneamino)-2-methyl quinazolin-4-(3H)-one (4g) exhibited better antiinflammatory
activity when compared to standard indomethacin. From the above results it may
concluded that compounds containing electron donating groups exhibits better analgesic activity
than electron withdrawing groups. The substituted phenyl ring at 3rd position in the synthesized
compounds was found to possess promising anti-inflammatory activity than unsubstituted phenyl
ring.
