The work focuses mainly on sustaining the release of Cefuroxime axetil by formulating them in to matrix tablets by using various matrix materials alone/ or in combination with ethyl cellulose (bees wax, lanatte wax, guar gum, xanthan gum, ethyl cellulose). The formulated tablets were subjected to evaluation by in vitro release studies. The release kinetics of the matrix tablet was also investigated in the work.