During a descriptive study from October 2007 to March 2008, 100 known Schizophrenia patients visiting psychiatry clinics in Razi and Sina hospital as well as patients hospitalized in Razi hospital were studied. These patients according to existence of dermatologic problems were divided into groups with and without problems. The incidence of dermatologic problems and prescribed drugs were compared between two groups. Then case group was studied about onset of the disease, other co-morbidities and other proposed diagnosis.Significant differences were found in Olanzapine, Halopridole, Perfenazine, Respridone and lithium among case and control groups. Most (68.31%) of dermatologic diseases had stable progress. itching (40.9%) and akin wounds (2.7%) were the most argument of patients. Distribution of dermatologic problems were mostly (52.3%) in limbs. Epilepsy was the prevalent co-morbidity in these patients.In this study, many different types of dermatologic disease were seen in Schizophrenia patients. According to wide use of antipsychotic drugs in Schizophrenia patients and our findings, purposing the incidence of complications during using these drugs is important and should take into regard some actions in preventing or treating their complications by following the patients.