Hypertension, smoking, and hyperlipidemia are main causes of Myocardial Infarction. In recent years other factors such as chronic and persistent bacterial and viral infections are considered as causes of chronic inflammatory reaction in blood vessels leading to atherosclerosis. One hundred sera of patients with Myocardial Infarction and 76 sera of controls is examined by commercial ELISA kits to measure IgG to cytomegalovirus, Chlamydia pneumonia, Mycoplasma pneumonia ,and Helicobacter pylori. C - reactive protein, highly sensitive- C-Reactive Protein, and ASO are also measured by commercial kits. Seropositivity to cytomegalovirus, Chlamydia pneumonia , and Helicobacter pylori. Showed significant relationship to occurrence of myocardial infarction but not for Mycoplasma pneumonia. C - reactive protein and highly sensitive- C-Reactive Protein also Showed significant relationship with myocardial infarction but not ASO. Some chronic and persistent infections other than common risk factors of Myocardial Infarction can induce inflammatory changes leading to atherosclerosis in coronary arteries and promote occurrence of Myocardial Infarction.