Avena sativa sometimes called the common oatis a species of cereal grain grown for its seed, which is known by the same name (usually in the plural, unlike other cereals and pseudocereals).The aim of this study was to overview its therapeutic effects than its nutritive and industrial effects. This review article was carried out by searching studies in PubMed, Medline, Web of Science, and Iran Medex databases .The initial search strategy identified about 128 references. In this study, 1 13studies was accepted for further screening and met all our inclusion criteria [in English, full text, therapeutic effects of Avena sativa and dated mainly from the year 1964 to 2015.The search terms were “Avena sativa.”, lemon balm, “therapeutic properties”, “pharmacological effects”. It is commonly used for cognitive function, antioxidant effect, anti-thrombosis effect, anti-inflammatory activities, Pro-apoptotic properties, pharmacology, and hemodialysis. Avena sativa is widely used for therapeutic and non-therapeutic purposes that trigger its significant value. Various combinations and numerous medicinal properties of its extract, oil, and leaves demand further and more studies about the other useful and unknown properties of this multipurpose plant.