Vincristine is an established drug of choice in treatment of some myelomas, lymphomas and leukemia. Nephrotoxicity is a lesser studied side effect of the drug. : In this study were done on 40 adult male mice. Mice were divided randomly into 2 groups (Control and treatment). In treatment group were received vincristine as I.P in 3 weeks (single dose in each week). In the end mice were scarified and kidney were gathered and fixed to staining with H&E and Masson's Trichorome. According to the observation performed, The Vincristine induced a necrotic effect on proximal convoluted tubular epithelial cells, that result destroyed brush borders and making of proteinaceous debris. Furthermore a hyaline droplet was observed in collecting ducts. There was also a meaningful relation in the statistical analyses of comparing treatment and control group parameters (p<0.05).
