Diabetes and acute pancreatitis are major health concern globally. India has been growing as a diabetic capital of the world. Diabetes and acute pancreatitis were induced by administration of Alloxan intraperitoneally 150mg/kg.b.wt in to Wistarnorvegicus. Diabetes induction was confirmed by blood glucose concentration above 400mg/dl. The desired plant Tinospora cordifolia (250mg/kg.b.wt) stem extract showed significant remedial action by lowering blood glucose to normal (87mg/dl) and restoring Pancreatic enzymeslipase to (1.74IU/L) and amylase to (583.1IU/L). These results were further authenticated by remodeling of pancreatic histoarchitecture which showed increase in no. Islet of Langerhans, acinar cells, decreased vacuolar space, sinusoidal space and atrophy.
