The Present investigation deals with the preparation and evaluation of proniosomes of simvastatin using non-ionic surfactant like span 60, cholesterol and maltodextrin in various proportions and evaluation of performance of prepared proniosomes in tablet dosage form. Proniosomes were prepared by slurry method. Proniosomes and tablets were evaluated for In-vitro drug release study, solid state characterization and results of dissolution study was compared with marketed formulation. Proniosomes showed very poor drug release because drug was molecularly dispersed in span 60, cholesterol and which may effect on the drug release. The prepared tablet formulation showed improvement in dissolution rate due to presence of hydrophilic carrier like a maltodextrin and other hydrophilic tablet excipients. Thus, the developed proniosomal tablet formulation of simvastatin improve dissolution rate in comparison with marketed formulation and may leads to enhancement of bioavailability of simvastatin.
