Ethanolic extracts of leaves of Clerodendrum infortunatum Linn, Argyreia nervosa and Vitex negundo were subjected to preliminary screening for antimicrobial activity .All ethanolic extracts exhibited significant anti-microbial activity comparable to the standard drug tetracycline. Ethanolic extract of Clerodendrum infortunatum shows more inhibitory zone as compared to ethanolic extracts Argyreia nervosa of and Vitex negundo. The mixture of all three extracts together in equal concentration shows more inhibitory zone as compared to other extracts.