Der Pharmacia Lettre
Abstract
Author(s): Sivakumar Ramakrishnan*, Rajendran N and Narayanan N
The aim of the study was to apply statistical optimization technique for the development of ketoprofen loaded
mucoadhesive multiparticles to target the small intestine. The mucoadhesive multiparticles were prepared by
quassi- emulsion solvent diffusion method and filled in enteric coated capsules. All the formulations were
characterized for particle size, mucoadhesion, drug loading, entrapment efficiency, in vitro release studies. A 32
factorial design was used to optimization. The dependable variables were PVA concentration (X1) and rotational
speed of stirring elements(X2). The chosen response variables were particle size (Y1), percentage of drug release
for 24 h (Y2), mucoadhesion (Y3) and entrapment efficiency (Y4). The optimized formulation according to the study
was mucoadhesive microspheres prepared with 0.5% w/v of PVA and 400 rpm of stirring speed i.e ( -1, +1). The
results of this optimized formulation showed with mean particle size of 225.5 �Ž�¼m, percentage of drug release for 24
h 97%, 83.43% of mucoadhesion and 88.4% of entrapment efficiency.
