The physico-chemical status of water samples from five major part of locality in Karur and Tiruchirappalli cities, Tamil Nadu was assessed. The sampling points were selected on the basis of their importance. The physicochemical parameter like, temperature, pH, electrical conductivity (EC), total dissolved solids (TDS), dissolved oxygen (DO), total hardness (TH), calcium (Ca) magnesium (Mg), sodium (Na), potassium (K), nitrate (NO3) sulphate (SO4) and phosphate (PO4) of ground water was determined. The results were compared with standards prescribed by WHO (2003). It was found that the ground water was contaminated at few sampling sites namely Mayanur, lalapet and Petavaithalai. While the sampling sites showed physicochemical parameters exceed the water quality standards and the quality of water is bad and it is not fit for drinking purpose. For the statistical analysis, correlation co-efficient (r) were also calculated for these water quality characteristics.