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Some Transformations of Benzimidazolyl Chalcones Using MAOS Protocol- A Green Approach | Abstract
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Abstract

Some Transformations of Benzimidazolyl Chalcones Using MAOS Protocol- A Green Approach

Author(s): Janardan Singh Yadav, Jayanti Rajora and Y. K. Srivastava

Benzimidazolyl Chalcones(1) were treated with isonicotinoyl hydrazide (1NH) to afford N1
isonicotinoyl -3-benzimidazolyl -5- aryl -2- pyrazolines(2). Reactions of (1) with ethyl
acetoacetate in presence of basic alumina gave 6-Carb-ethoxy-3-benzimidazolyl-5-aryl
cyclohexenones(3) which on treatment of hydrazine hydrate gave 6-benzimidazolyl-4-aryl 3-oxo-
2,3,4,5 tetrahydro-1H-indazoles(4). All the transformations were carried out under microwave
assisted condition. The synthesized compounds were screened for their antimicrobial activity in
vitro.