The present study highlights some important medicinal plants used in Gingee Taluk of Villupuram district, Tamil Nadu, India. Medicinal plants have been continuously used to cure various ailments both for human beings and veterinary uses in the study area. Extensive field surveys are conducted in 8 villages among the traditional users, herbal practitioners, elders, farmers and women. The information on medicinal plants are collected using a standard questionnaire. Information on medicinal plants with their local names, parts used, mode of preparation and mode of administration are carefully recorded. A total number of 15 informants are selected and interviewed based on their knowledge of medicinal plants and practice of herbal medicine either for self-medication or for treating others. The present study shows that the informants in Gingee Taluk have very good knowledge on the medicinal plants used for various ailments.