Tobacco smoking is arguably the most important preventable cause of cardiovascular disease. This present study was undertaken to determine some cardio-pulmonary and cardiovascular parameters effects among smokers and non-smokers students of Ahmadu Bello University, Zaria Nigeria. A total of 200 male students between the age ranges of 20-30 years were used in the study. 100 students were smokers (test group) and 100 students were nonsmokers (control group). The results showed a significantly increase (p<0.05) systolic and diastolic blood pressure levels in smokers when compared to non smokers. There was also a significant decrease (p<0.05) peak expiratory flow rate of smokers when compared to non smokers. The mean values of pulse pressure in smokers, there was a significant increase (p>0.05) when compared to non smokers. In conclusion smoking increases the systolic and diastolic blood pressure and decrease the peak expiratory flow rate.