In the present study Thermo and PH responsive smart polymers were utilized to overcome the problems encountered for the ophthalmic formulation which normally get drained,short ocular residence once instilled by formulating the smart ophthalmic gels that shows Newtanion flow easy to administer the same get transformed in to gel on contact with eye site due to lachrymal PH and physiologic temperature. With such a systems one can increase the contact time of the drug with the localised site and increase bioavailabity which is normally desired for the treatment of ocular infection with ciprofloxacin Hcl.. The prepared formulations where passed all the Physico-Chemical examinations and sterility test and results illustrates that with increase in the polymer concentration increases the viscosity and decreases the drug release. Formulation F3 compounded with Polyacrylic Acid ( Carbopol 934 ) 0.3% and Pluronic F 127 (PF 127) 12% was considered to be the best amongst all the five with 94.5% drug release upon 8th hour diffusion study, 60.5 Cps non-physiologic, 100.2 Cps physiologic condition viscosity respectively and 99.35% drug content with no chemical interaction as per FT-IR spectra.
