The present study describes simple, accurate, precise and cost effective UV Spectrophotometric method for the simultaneous estimation of Amlodipine besylate (AMD) and Losartan potassium (LP) in bulk and tablet dosage form. The solvent used was methanol and the absorption maxima for amlodipine besylate and losartan potassium were found to be 237nm and 202nm respectively. A linear response was observed in the range of 1.25-7.5μg/mL and 12.5-75μg/mL with a correlation coefficient of 0.99 for AMD and LP respectively. The method was then validated for different parameters like accuracy, precision, sensitivity and linearity as per ICH Q2 (International Conference on Harmonization) guidelines. This method can be used for the simultaneous estimation of AMD and LP in quality control of formulation without interference of excepients.
