Der Pharmacia Lettre
Abstract
Author(s): Vinit D. Patil, Vinayak J. Kadam, Santosh N. Shinde, Aniruddha R. Chabukswar,
Swati C. Jagdale, Bhanudas S. Kuchekar
The method for the simultaneous determination of Mefenamic acid and Ethamsylate by
spectroscopy has been developed. The simple, accurate and precise method includes Area Under
the Curve (AUC) method. From a solvent effect studies and the spectral behaviours of
Mefenamic acid and Ethamsylate, methanol was selected as solvent. Mefenamic acid shows
maximum absorbance at 337 nm and Ethamsylate shows maximum absorbance at 306 nm. For
the AUC method, the wavelength ranges between. 337-344 nm and 300-306 nm were selected
with reference to the absorbance curves plotted between the wavelengths of 200-400 nm. This
method allows rapid analysis of two drug combination. The results of analysis were validated
statistically and by recovery studies by following ICH method validation guideline. Tablet
containing both drugs was assayed using the methods developed, showing a good accuracy and
precision.
