This paper describes validated First Derivative Spectrophotometric method for the simultaneous estimation of Azelnidipine and Olmesartan medoxomil in synthetic mixture. Quantitative determination of the drugs was performed at 239.4 nm and at 217 nm (N = 1; Δλ = 1) for Azelnidipine and Olmesartan medoxomil, respectively. Proposed method was evaluated for the different validation parameters. The specificity test showed that there was no interference from excipients commonly found in the commercial pharmaceutical formulations at the analytical wavelengths of Azelnidipine and Olmesartan medoxomil. Quantification was achieved over the concentration range of 4 – 32 μg/ ml for Azelnidipine and Olmesartan medoxomil disoproxil fumerate. The mean recovery was 100.48 ± 1.011 and 100.70 ± 1.090 % for Azelnidipine and Olmesartan medoxomil, respectively. This method is simple, precise, sensitive and applicable for the simultaneous determination of Azelnidipine and Olmesartan medoxomil
