Pefloxacin (PEF) is a well-known fluoroquinolone effective against both Gram-positive and Gram-negative bacteria. Due to its great therapeutic importance, simple method has been proposed for the spetrophotometric determination of this drug. Ceric ammonium sulphate (CAS) is used for the oxidation of PEF and the excess oxidant is determined by using either xylene cyanol FF (XCFFF) or safranin O (SO). The calibration graphs are found to be linear over 15.00–35.00 and 10.00–60.00 μg mL−1 with molar absorptivity values of 2.05 × 104 and 2.95 × 104 L mol−1cm−1 for PEF-XCFF and PEF-SO, respectively. The methods have been successfully applied for the determination of drugs in pharmaceutical dosage forms.
