This research was undertaken to determine the seroprevalence of HCV among patients attending antiretroviral therapy (ART) clinics in some parts of Abuja and Nasarawa States, Nigeria. A total of 522 sera samples were collected between March and August 2019, from HIV patients, recruited in the ART clinics of selected hospitals. Samples were screened using immunochromatographic assay, followed by a third-generation Enzyme-Linked Immunosorbent Assay (ELISA). 154 (29.5%) of these samples were from male patients, and 368 (70.5%), females with a ratio of 1:2.4. The mean age ( ± SD) of the patients was 38.0 ( ± 9.56). The presence of hepatitis C virus coinfection was observed in 82 (15.7%) patients. The male population had a higher co-infection rate (17.5%) than the female population (14.9%). Patients aged 31-40 had a higher hepatitis co-infection (6.7%) rate than the other age groups. Blood transfusion, sharing of sharp objects, and the number of sex partners were significantly associated with HCV co-infection. This study revealed high endemicity of hepatitis C virus co-infection with HIV in the study region. Preventive measures are thus advocated to curb the spread of the viral infection.
