The entry of detergents into wetlands may have adverse impact on the fishes inhabiting it. With this view the present study was initiated to evaluate the toxic stress induced by Sodium dodecyl sulphate (SDS) in fish Puntius parrah by using haematological parameters as a diagnostic tool. The variation in haematological parameters (Red Blood Cell, White Blood Cell, Haemoglobin, Mean Corpuscular Volume, Mean Corpuscular Haemoglobin, Mean Corpuscular Haemoglobin Concentration) in SDS exposed Puntius parrah evidenced in this study could be due to the mechanism by which it overcome toxic stress. The immune response elicited by the fish towards SDS is evidenced in the form of significant elevation in White Blood Cell count.