The ethanolic extract of some weeds were tested against human pathogen Staphylococcus aureus which cause skin infection and found that alcoholic extract was more toxic against this pathogen. Phytochemical analysis of various parts of the weeds were screened and found that alkaloids, flavonoids, terpenoids, steroids, phenolic compounds, saponins and glycoside were present. Out of these some chemical compounds provide protection against pathogenic infection.