Two plants Tamarindus indica and Detarium microcarpum used in Tiv land for treatment of diarrheal infection were screened for their antibacterial potentials. The purpose of the screening is to justify and endorse the use of these plants in ethno-medicine or folklore as traditional treasure to cure diarrheal infection. The phytochemical screening shows secondary metabolites of high therapeutic concern, the alkaloids ,flavonoids, phenols , Tannins, etc,. The antibacterial screening of the stem bark of Detarium microcarpum and root bark of Tamarindus indica shows clear zones of inhibition, by agar well diffusion, demonstrated by the Hexane, ethyl acetate, chloroform and methanol extracts of these plants against the tested bacterial species, which constitutes the etiological agents for the Diarrheal infection. The result of the research provides satisfactory scientific backing for the traditional use of the various extracts of these plants.