Soybean a species of legume native to East Asia belonging to Fabaceae family .it is a cheap source of protein. This review article was carried out by searching studies in PubMed, Medline, Web of Science, and IranMedex databases up to 2016. Eighty three articles was found, of which 50 articles were included. The search terms were “soybean”, “therapeutic”, “pharmacological”, "Chemistry". Various studies have shown that soybean possess anti-Cancer, vaginal atrophy, lipid-improving effect, antidepressants effect, reproductive effects, anti-menopausal effect, bioavailability effect, estrogen effect, Anti-osteoporosis effect. Various combinations and numerous medicinal properties of soybean extract is shown it deserve more studies about the other useful and unknown properties of this multipurpose plant.