Scale-up of mixing operations continues to present a concern to the pharmaceutical development process. There liable scaling of a process requires an understanding of the effects that processing parameters may illicit on intermediate- and finished-product properties. V-blenders, tote blenders, and double-cone blenders are examples of batch blenders that vary in geometric design .For these systems, variables such as blender size and fill level may affect mixing behavior The main variables known to affect mixing performance are: (1) the design of the mixing system (e.g., geometry and blend mechanism), (2)blender size, (3) the fill level, (4) the blender loading mode, (5) the speed of rotation of the blender, and (6)the material properties of the ingredients being mixed(particle size, shape, and density, etc This paper discusses the Scale Up factor determination of V Blender and Understanding mixing mechanisms and identifying critical process and material parameters is often a crucial step during process development. Content uniformity problems have four main root causes: (a) powder stream flow properties, (b) poor equipment design or inadequate operation, (c) particle segregation due to differences in particle properties, and (d) particle agglomeration, driven by electrostatics, moisture, softening of low melting point components, as well as other factor As a result, unless the effects of all variables are nearly independent of one anothe
