The quest for save herbal remedy for the management of cardiovascular diseases prompted this investigation and itis aimed at determining the effect ofSaponin from Solanum anguivi fruits on serum lipid profile - a risk factor in thedevelopment coronary heart disease (CHD).Thirty six (36) rats(Rattusnovergicus) of average weight (125± 12g) were divided into six (6) groups of six animals each designated as A (n=6, 2.0ml distilled water), B (n=6, 20mg/kg saponin), C (n=6, 40mg/kg), D (n=6, 60mg/kg), E (n=6, 80mg/kg), and F (n=6, 100mg/kg). Saponin was administered orally once daily to groups B,C,D,E and F for (21) days.Serum lipid profile was determined usingdiagnostic kits. The result showed an initial significant increase (p<0.05) in weights of the treated animalswhen compared with thecontrol but by the third week, the increase was not significant. A significant reduction (P<0.05) in serum Triglycerides, total Cholesteroland Low-Density Lipoprotein(LDL) was observed while High-Density Lipoprotein (HDL) was significantlyincreased. The dose dependent effects of saponin from Solanum anguivi fruit on serum lipid profile is very crucial, as it may reduce the risk of developingCHD. Saponin from Solanum anguivi fruits has hypolipidemic potential which is one of the greatest risk factors contributing to the prevalence andseverity of coronary heart diseases
