A new RP-HPLC method has been developed and validated for determination of Zaltoprofen in bulk and tablet dosage form. The estimation was carried out on Enable C18G (250 mm ×4.6 mm, 5 μm) column using Acetonitrile and 0.1% v/v Acetic acid in the ratio of 95:5 % v/v as mobile phase. The flow rate was 1.0 ml/min and the effluent was monitored by UV detector at 331 nm. The retention time was 3.688 min and linearity was observed in the concentration range of 10-60 μg/ml. The percentage recovery was in good agreement with the labelled amount in the pharmaceutical formulations and the method was simple, precise and accurate for the determination of Zaltoprofen in bulk and pharmaceutical formulation.
