Coronary artery disease (CAD) is a leading cause of death in the western world. Cardiovascular disease (CVD) is a leading cause of mortality and is responsible for one-third of all global death India, for example, approximately 53% of CVD deaths are in people younger than 70 years of age: in china the corresponding figure is 35%. The majority of the estimated 32 million heart attacks and strokes that occur every year are caused by one or more cardiovascular risk factors – hypertension, diabetes and etc. Our review article mainly focused on role of antioxidants and oxidative stress in cardiovascular diseases. We developed a search strategy to find publications about CVD and its Oxidative stress management. So, we searched Science Direct, Medline and PubMed bibliographic databases using the key phrases causes of CVD, antioxidants, oxidative stress, management of CVD and drugs under clinical trials. Our review article results, list out of clinical research studies done in Oxidative stress and antioxidant status in cardiovascular patients during 1999-2009. It has been concluded that, evidences suggesting increase intake of antioxidants to be protective in cardiovascular diseases. However, irrational and non judicial use of antioxidants can also increase the risk of potential toxicity. In spite of best recommended action is to increase the intake of natural dietary antioxidant vitamins are good for health.
