The purpose of present study was to evaluate the testes and epididymides mediated reversible contraceptive efficacy of ethanol extract of Tinospora cordifolia stem at the dose level of 400mg/kg. b.wt./rat/day. Oral treatment of 60 days caused significant reduction in number of spermatozoa in cauda epididymides as well as in testis with a decreased in the motility of sperm collected from cauda epididymides. The weight of testis, epididymis and seminal vesicle was also significantly reduced in case of treated animals when compared to control. Moreover, Tinospora cordifolia extract did not alter the hematological parameters, which shows its nontoxic nature. All these parameters were reversible after withdrawal of the treatment. In conclusion ethanol extract of Tinospora cordifolia stem have reversible contraceptive activity in male rats.
