A simple, reproducible method was developed for the determination of levocetirizine and pseudoephedrine in tablet formulation using reverse phase HPLC method. HPLC separation was carried over on a Thermo hypersil – keystone C18 (250 x 4.6mm, 0.5m) isocratic mode column using a mobile phase comprising a 50:50 (% v/v) of acetonitrile and 0.5mM phosphate buffer. The detection was proceeded out by UV detector at 257 nm. The range taken for linearity for levocetirizine and pseudoephedrine were 5 – 25 mg/ml and 120 – 600 mg/ml. The percentage recovery was 100.11 % and 110.04 % for levocetirizine and pseudoephedrine respectively. The amount of levocetirizine and pseudoephedrine found per tablet was 5.05 mg and 119.84 mg respectively.
