The employment of many synthetic chelators like ethylenediamine tetraacetic acid, increase the mobility and bioavility of the heavy metal uptake by plants and favoring their accumulation in the aerial parts of phytoextracting plants, also the particularly participation of plant growth-promoting bacteria prevent the deleterious effects of environmental stresses by the stimulation of plant growth through the synthesis of phytohormones and by the secreted siderophores that may improve the metal bioavailability. The aim of this study was analyze the effect of the inoculation of Sedum praealtum roots with a siderophore producing bacteria (SPB) and EDTA in the release of metabolites and root enzymatic activity as a physiological response to cadmium. In Sedum praealtum roots, Cd doesn´t inhibit the guaiacol peroxidases activity, considering it as protecting mechanism against the heavy metal. The correlation between the IAA and CAS released and quantified in the medium showed the effect of the rhizobacteria Pseudomonas sp. Sp7E employed as inoculant and the chemical chelator to enhance a protecting response of Sedum praealtum roots to Cd.