Aflatoxine the major toxic metabolites of fungi which are able to induce chronic liver damages. The antioxidant and hepatoprotective effects of Ginseng extract and probiotic on Alfatoxin was investigated. Alfatoxicosis causes significant increase in liver enzyme SGOT and SGPT, Alkaline phosphatase activity and an increase in the level of cholesterol total lipid, decrease the level of total protein and haemoglobin and P.C.V. Moreover, the liver exhibited some clinicopathological changes and decreased body weight. Both Ginseng extract and probiotic reduced the development of hepatotoxicity by Aflatoxin. probiotic showed more improvement of all enzymes of kidney and liver, and also total lipid and cholesterol were reduced