Quorum Sensing (QS) is a prevalent communication process found in most bacteria. Biofilm formation is believed to be responsible for antibiotic resistance in Pseudomonas aeruginosa. Quorum Quenching (QQ) is an antagonistic mechanism performed by certain bacteria against QS, where they degrade the QS molecule. In this study, pigment producing and biofilm forming P.aeruginosa was isolated from air. This quorum sensing organism was co-cultured with two soil isolates – Brevibacillus brevis and Bacillus subtilis, and their inhibition against quorum sensing organism was studied using crystal violet assay. Brevibacillus brevis was found to show antagonistic activity. Both the organisms were found to inhibit the biofilm formation.
