Quantitative structure-activity relationship of twenty nine benzene sulfonamides as inhibitor of carbonic anhydrase based on quantum chemical descriptor, heat of formation, molecular weight, total energy, energy of highest occupied molecular orbital, energy of lowest unoccupied molecular orbital, electronegativity and absolute hardness, has been studied. The purpose of the study is to test the suitability of the above quantum chemical parameters as possible biological activity descriptor in the development of QSAR. We have considered 83 QSAR models using, multiple linear regression, MLR, analysis with the help of various combinations of the descriptors. In order to explore the reliability of the proposed model we have used regression coefficient, r^2, and cross-validation coefficient, rCV^2. The study shows that heat of formation, molecular weight, total energy and energy of highest occupied molecular orbitals of the benzene sulfonamides can be used as descriptors of biological activity.
