Der Pharmacia Lettre

Abstract

Quantification of genotoxic impurities in amlodipine drug substance by LC-MS

Author(s): Metta Srinivasa Rao, Sumathi Vinay Rao, Kollisetti Prasanna Ramesh Babu, Pallerla Satish Kumar and Hemant Kumar Sharma

LC-MS Single ion monitoring (SIM) method has been evaluated for the determination of genotoxic impurities
(Methylbenzene sulphonate, Ethylbenzene sulphonate and Isopropylbenzene sulphonate) in Amlodipine drug
substance. These are the potential genotoxic impurities were quantified at lower levels by using LC-MS

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