This paper presents Flavonoid and phenol content of methanolic and aqueous extract of the stems of the plant Macrosolen parasiticus (L.) Danser, Loranthaceae, an important plant in the Indian system of medicine. Macrosolen parasiticus (L.) Danser a parasitic plant belongs to the family Loranthaceae commonly known as mistletoes. The family comprises about 60 genera and 700 species and is widely distributed in all tropical regions and also in the southern land masses. Its species are mostly woody perennials which occur as aerial parasites of other dicotyledons. In the present study the Flavonoid and phenol content of methanolic and aqueous stem extract of Macrosolen parasiticus was evaluated by the method Singleton A.L et.al and Chia-Chi chang et.al respectively.Total phenolic content for methanolic and aqueous extracts were found to be 88 and 122 mg/g and total flavonoid content were found to be 22.5 and 6.8 mg/g.