The ethyl acetate soluble and insoluble fraction of the methanolic extract of the aerial parts of Amaranthus spinosus Linn (Family: Amaranthaceae) were evaluated for hepatoprotective activity in Paracetamol induced liver damaged rats. Both the fractions, at a dose of 200mg/kg/p.o were administered through oral route for 7 days. The ethyl acetate soluble fraction exhibited a significant hepatoprotective effect by lowering serum levels of glutamic oxaloacetic transaminase (SGOT), glutamic pyruvic transaminase, (SGPT), alkaline phosphatase (ALP), total bilirubin (TBL) and increase in serum total protein levels (TPL). These biochemical observations were also evidenced by histopathological examination of liver sections. The activity was compared with standard drug Silymarin.
