Proteases are one of the most common enzyme families in the world. Proteases have been used more effectively in recent years in fighting cancer. There are numerous reviews in the literature about the interaction of proteases with cancer. They usually focus on the entire cancer rather than focusing on a part of the cancer. This review generally focuses on angiogenesis (clearest stage for intervention), which is the most critical stage of cancer in the scientific world. In this review, searching of literature on the interaction of protease enzymes with angiogenesis, a very critical stage of cancer has been made into a summary table. With this study, it is envisaged that researchers can access information more easily and comparatively.