Der Pharmacia Lettre
Abstract
Author(s): Kiran Yadav, Deepak Yadav, Kamal Saroha, Sanju Nanda, Pooja Mathur, Navneet Syan
Over the last few years a comprehensive research has been done over proniosomal gel as a
provesicular approach for transdermal drug delivery. However skin has a very tough diffusion
barrier that is lipid bilayer in the stratum corneum inhibiting penetration of drug moiety which is
rate limiting barrier for penetration of drugs. Vesicular systems (niosomes & liposomes) are
promising systems to cross this permeation barrier. They may act as vehicles or as permeation
enhancer for bioactive materials to enhance their penetration via stratum corneum. But their
major drawback is their unstability, which can be overcome by utilizing provesicular approaches
like proniosomes. Proniosomes (gel) are semisolid liquid crystal products of nonionic
surfactants easily prepared by dissolving the surfactant in a minimal amount of an acceptable
solvent (ethanol) and the least amount of aqueous phase (water). Proniosomal gel offers a great
potential to reduce the side effects of drugs and increased therapeutic effectiveness. Proniosomes
can entrap both hydrophilic and hydrophobic drugs. In this review we have covered
proniosomal drug delivery along with preparation, formulation and evaluation parameters of
proniosomes as drug carrier.
