Tuberculosis (TB) is an infectious disease caused by the bacterium Mycobacterium tuberculosis. One of the factors which cause increasing incidence of antibiotic resistance is a patient noncompliance. This study aimed to examine the prevalence of pulmonary tuberculosis from 2014-August 2016, to measure the level of compliance and the factors that influence patient compliance in the use of antibiotics. This study was carried out for 3 months using cross sectional method study in Andalas District Health Centre Padang. Assessment of compliance on a prospective basis using Morisky Medication Adherence Scales (MMAS-8) and pill counting method as well as sputum data of respondents’. Data were analyzed using Chi-square analysis. The results showed the number of pulmonary patients have decreased in the sequence year. A total of 22 patients categorized based on their compliance. The MMAS-8 data showed 16 (72.73%) patients comply with their treatment and 6 patients (27.27%) were non-compliant. The pill counting data showed all respondents (100%) complied with their treatment. However, sputum data revealed 2 patients still had positive result until 5th month of treatment. Factor affecting of patient non-compliance were the medication had the bitter taste (100%) and unpleasant side effects (83.3%). Statistical analysis found the factors which have a significant relationship was education level (p = 0.039).
