Gastroretentive dosage forms have potential for use as controlled-release drug delivery systems. Multiple unit systems avoid the all-or-none gastric emptying nature of single-unit systems. A controlled release system designed to increase its residence time in the stomach without contact with the mucosa was achieved through the preparation of Microballoon delivery system by emulsion solvent diffusion method. The effect of various formulation and process variables on the internal and external particle morphology, micromeritic properties, in vitro floating behavior, physical state of the incorporated drug, drug loading and in vitro drug release was studied. Formulation demonstrated favorable in vitro floating and release characteristics. The drug encapsulation efficiency was high. Domperidone loaded microballoons proved desired release behavior and buoyancy. The designed system, combining excellent buoyant ability and suitable drug release pattern, could possibly be advantageous in terms of increased bioavailability of Domperidone. Domperidone loaded Microballoon was found to be stable at various conditions.
