The purpose of this research was to find out the taste masking effect of Kollicoat Smart Seal 30 D with different super disintegrants in formulation and evaluation of Paracetamol oral disintegrating tablet. Nine such formulations of oral disintegrating tablets were prepared by wet granulation technique using superdisintegrants as main ingredients, along with other excipients in various concentrations. Coating of the granules was achieved by 33.33% w/v of Kollicoat Smart Seal 30D Suspension prior compression. Compatibility study of the drug and excipients were carried out by FTIR study. The prepared tablets were evaluated for post compression parameters like thickness, weight variation, content uniformity, hardness, friability, and disintegration time, dissolution study and stability study. The taste of the formulations was analyzed by the responses of healthy volunteers. The formulations varied in disintegration time and taste masking property. Out of these formulations F6 and F7 showed good disintegration and taste masking property than others. So F6 and F7 were subjected to three months stability study and it was observed that F6 and F7 retained its property of an oral disintegrating tablet. Thus a taste masked oral disintegrating Paracetamol tablet which disintegrates within 30 sec in the mouth can be prepared with Kollicoat smart Seal 30 D.
