Matrix tablets of Indomethacin were prepared by wet granulation method. Guar gum and Pectin as a carrier, 10% starch paste, Dicalcium phosphate is used as diluents and the mixture of talc and magnesium stearate at 2:1 ratio were used. All the prepared formulations were evaluated for hardness, drug content uniformity and were subjected to in vitro drug release studies with and without rat caecal contents. The highest in vitro dissolution profile at the end of 24 h was shown by F1 followed by F7, F8. The other formulation F2, F3, F4, F5, and F6 were failed to target in colon and these formulation releases the majority of drug within 10 h of study.
