Der Pharmacia Lettre
Abstract
Author(s): Parag A. Kulkarni, Santosh B. Jawale, Mahendre K. Jaiswal, Abhijit D. Kulkarni, Satish V. Shirolkar, Pramod V. Kasture
The goal of the present study was to develop a floating mutiparticulate drug delivery system
based on gas formation technique, in order to prolong the gastric residence time and increase
the overall bioavailability of the drug from dosage form. The system consists of the core pellets
which are coated with three different layers, inner layer of drug, middle layer of effervescent
material alongwith binder polymer (sodium bicarbonate) and an outermost of gas-entrapped
sustained release polymeric membrane (EudragitÃ?â??Ã?® RSPO: RLPO). The time to float increased
as the coating level of gas-entrapped polymeric membrane increased. The optimum system could
float completely within 2 min. and maintained the buoyancy over a period of 24 h. The drug
release was sustained and linear with the square root of time. Increasing coating level of gasentrapped
polymeric membrane decreased the drug release. Both the rapid floating and the
sustained release properties were achieved in the floating multiparticulate drug delivery system
developed in this current study.
