Der Pharmacia Lettre
Abstract
Author(s): Kamlesh Kumari, Vijay Sharma, Betty Philip, Kamla Pathak
The aim of this work was to assess the advantage of ternary complexes of itraconazole over its
binary complex with �Ž�²-cyclodextrin (�Ž�²-CD) so as to explore the possibility of further improving
the solubility, dissolution rate and complexation efficiency of itraconazole -�Ž�²CD by addition of
auxillary substance plasdone S-630. The phase solubility study performed in the presence of
fixed amount of plasdone S-630 showed a linear, AL type diagram with a seven fold enhancement
in the complexation efficiency and the stability constant was calculated as 887.60 M-1. Of the
various preparation techniques used ternary complexes prepared by freeze drying exhibited
highest %DE90 of 30.12. The freeze dried and microwave irradiated itraconazole -Ã?ŽÃ?²CD Ã?¢Ã?â?¬Ã?â??
plasdone S-630 terneray complexes were characterized by SEM, XRD, DSC and 1HNMR.
