Der Pharmacia Lettre
Abstract
Author(s): Suresh D. Kumavat*, Yogesh Chaudhari, Pallavi Duvvuri, Jigar Desai and Franklin QuadraS
The aim of this study is to enhance the solubility of poorly water soluble drug Glibenclamide via the Solid
Dispersion technique by Spray drying method. Solid dispersions (SD) of Glibenclamide-Plasdone S630in the ratio of
1:1, 1:2, 1:4, 1:6 and 1:8 were prepared in an attempt to increase the solubility and dissolution rate of the drug.
Solubility, dissolution, Scanning electron microscopy (SEM), differential scanning calorimetry (DSC) and Fourier
transform infrared spectroscopy (FTIR) of solid dispersions, physical mixtures (PM) and glibenclamide were
evaluated. Both solubility and dissolution ofdrug solid dispersions were significantly greater than those observed
for physical mixtures and intact pure glibenclamide. The differential scanning calorimetry indicated that the high
energy amorphous glibenclamide was obtained from all solid dispersions. It was found that the optimum weight
ratio for Glibenclamide-Plasdone S630 is 1:8. The 1:8 solid dispersion shows highest Dissolution rate owing to its
amorphous nature and reduced particle size.
