Preparation of tablets dosage form from co-grinding of meloxicam with PVP K-30 has been done. Meloxicam and PVP K-30 in a weight ratio of 1:3 were grounded for 2 hours. The interaction of co-grinding solids state were evaluated by FT-IR. Tablets were prepared by direct compression method in three formulas: co-grinding of meloxicam (F1), physical mixtures meloxicam (F2), and intact meloxicam tablet (F3). The evaluations conducted for tablets were weight variation, size variation, hardness test, friability test, disintegration time, and tablet dissolution. Dissolution test was carried out for 60 minutes in phosphate buffer pH 7.5. The dissolution test results for F1, F2, and F3, were 71.65% ± 2.32; 51.66% ± 5.38; 35.71% ± 2.96, respectively. Co-grinding meloxicam tablet showed the highest dissolution rate compared to physical mixture and intact meloxicam tablet (p<0.05).
